Development of a new model system to dissect isoform specific Akt signalling in adipocytes
نویسندگان
چکیده
منابع مشابه
Development of a new model system to dissect isoform specific Akt signalling in adipocytes
Protein kinase B (Akt) kinases are critical signal transducers mediating insulin action. Genetic studies revealed that Akt1 and Akt2 signalling differentially contribute to sustain lipid and glucose homoeostasis; however Akt isoform-specific effectors remain elusive due to the lack of a suitable model system to mechanistically interrogate Akt isoform-specific signalling. To overcome those techn...
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Investigation of Histone Lysine-Specific Demethylase 5D (KDM5D) Isoform Expression in Prostate Cancer Cell Lines: a System Approach
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متن کاملInsulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.
The 3 Akt protein kinase isoforms have critical and distinct functions in the regulation of metabolism, cell growth, and apoptosis, yet the mechanisms by which their signaling specificity is achieved remain largely unclear. Here, we investigated potential mechanisms underlying Akt isoform functional specificity by using Akt2-specific regulation of glucose transport in insulin-stimulated adipocy...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2015
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20150191